Below is a link to the 1st part of a video of Dr. Randy Pausch's last lecture. He was a professor at Carnegie Mellon University and has terminal pancreatic cancer. This is his look at his life and lessons he has learned. I haven't watched the entire 1 hr-25 min lecture yet, but it is fascinating because he is funny, passionate, and reflective.
I'll add two more links that contain the entire lecture. Streaming from ETC Google Video. The lecture is broken into ten minute segments on Youtube.